Effectiveness of calcium channel blockade for organophosphorus and carbamate pesticide poisoning – study protocol for an open label, pragmatic, 3-arm RCT repurposing two widely available medicines

Fazle Rabbi Chowdhury, Suvodip Shaw, Abdullah Abu Sayeed, Soumitra Roy, Abu Shahin Mohammad Mahbubur Rahman, Nahida Zafrin, Pritish Tarafder, Muhammad Halimur Rashid, Aniruddha Ghose, Shishir Ranjan Chakraborty, Muhammad Khalilur Rahman, Muhammad Sayedur Rahman, Richard Parker, Muhammad Mahib Ullah, Zakir Hassan, Abdullah Al Mamun Sohag, Muhammad Robed Amin, Muhammad Shafiqul Bari, John Norrie, M. A. Faiz & Michael Eddleston

Toxicology Communications

27th November, 2023

Pesticide self-poisoning is one of the three most important global means of suicide, killing an estimated 110–168,000 people each year, mostly in poor rural Asian communities. Organophosphorus (OP) and carbamate anticholinesterase insecticides are responsible for about two-thirds of these deaths. Calcium channel blocking medicines (CCB) may reduce the effect of pesticides and prevent deaths.

Survey on sea snakebite and related morbidity and mortality among Bangladeshi fishermen in the Bay of Bengal: A pilot study

Aniruddha Ghose, Muhammed Syedul Alam, Abdullah Abu Sayeed, Mohammed Shah Jahan, Fateha Akter, Rabiul Alam Md Erfan Uddin, Shoman Sarkar, A.S.M. Zahed, Kajal Kanti Das, Md Habibur Rahman, Rumana Rashid, Hasina Nasrin, Asok Kumar Dutta, Md Ismail Khan, Ulrich Kuch, M.A. Faiz


29th August, 2023

Around two million people are engaged in marine fishing in the Bay of Bengal. Bites by sea snakes were common hazards feared by millions fishing at sea in earlier days. Current morbidity and mortality are also not known. This study was conducted to document and describe sea snake bites among selected communities of sea-going fishermen in Bangladesh.

Implementation of Ecological Distribution of Venomous Snakes for Clinical Management of Snakebite in Bangladesh

Ibrahim Khalil Al Haidar, Aniruddha Ghose, Mohammed Noman, Md Mizanur Rahma, Sajib Rudran, Abdul Auawal, Md Rafiqul Islam, Md Asir Uddin, Rabiul Alam Md Erfan Uddin, Abdullah Abu Sayeed, Md Robed Amin, Md Farid Ahsan, Md Abul Faiz, Mohammad Abdul Wahed Chowdhury.

Journal of Medicine

2nd July, 2023

Snakebite envenoming is a global health problem, mostly in tropical and subtropical countries. Bangladesh is a subtropical country facing thousands of snakebite envenoming death every year. Knowledge of the distribution of venomous snakes is necessary to identify snakebite-prone areas, develop strategies for prevention and management, and reduce venom-induced mortalities and morbidities.

Psychosocial Factors Behind Deliberate Self- Poisoning in a Tertiary Care Hospital of Bangladesh: A Cross-Sectional Study

Binayak Bhattacharjee, Soumitra Roy, M. M. Jahangir Alam, R. K. S. Royle, Shrebash Paul, Md Sohidul Islam, Md. Shafiqul Bari, Fazle Rabbi Chowdhury.

The Cureus Journal of Medical Science

6th February, 2023

Deliberate self-poisoning (DSP) is an important cause of hospital admissions and subsequent mortality. We conducted a cross-sectional observational study in a tertiary-level teaching hospital situated in the northeastern part of Bangladesh to analyze the psychosocial factors responsible for DSP.

Acute Poisoning in Bangladesh: A Systematic Narrative Review

Mohammad Jahid Hasan, Md. Kamrul Hassan, Zuhayer Ahmed, Md. Abdullah Saeed Khan, Jannatul Fardous, Tamanna Tabasssum, Fazle Rabbi Chowdhury, David Gozal, and Mohammad Robed Amin

Asia Pacific Journal of Public Health

20th November, 2022

Acute poisoning is a major public health concern and carries significant morbidity and mortality worldwide, including in Bangladesh. It is estimated that poisoning events are responsible for more than 1 million illness events and approximately 200 000 deaths annually. It is the seventh most common cause of hospital mortality in Bangladesh.1 Pesticides are the common mode of intentional poisoning in the Asian region,2 whereas organophosphorus compound (OPC) toxicity.

Management of Organophosphorus Poisoning: Standard Treatment and Beyond

Sakib Aman, Shrebash Paul, MBBS, Fazle Rabbi Chowdhury,

Critical Care Clinics

1st July, 2021

Self-poisoning with organophosphorus (OP) pesticide contributes to around 110,000 deaths per year worldwide.1 Globally, approximately 1 out of every 6 suicides is due to OP poisoning.1 Countries in South East Asia, China, and Africa bear the brunt of most cases, reflecting the extensive use of OP compounds in agriculture-dependent economies.

Organophosphorus poisoning: the wet opioid toxidrome

Michael Eddleston, Fazle Rabbi Chowdhury

The Lancet

20th December, 2020

In The Lancet, David Steindl and colleagues describe the case of a 44-year-old man who was poisoned by a novichok organophosphorus nerve agent. 1 The man was a passenger on a domestic flight in Russia when he became confused, and vomited and collapsed unconscious; 2 h later, he was hospitalised in Omsk, Russia, and treated for respiratory failure and coma. After transfer by air ambulance to Berlin, Germany, features of the cholinergic toxidrome (ie, small or pinpoint pupils, bradycardia, sweatin