Effectiveness of calcium channel blockade for organophosphorus and carbamate pesticide poisoning – study protocol for an open label, pragmatic, 3-arm RCT repurposing two widely available medicines
Fazle Rabbi Chowdhury, Suvodip Shaw, Abdullah Abu Sayeed, Soumitra Roy, Abu Shahin Mohammad Mahbubur Rahman, Nahida Zafrin, Pritish Tarafder, Muhammad Halimur Rashid, Aniruddha Ghose, Shishir Ranjan Chakraborty, Muhammad Khalilur Rahman, Muhammad Sayedur Rahman, Richard Parker, Muhammad Mahib Ullah, Zakir Hassan, Abdullah Al Mamun Sohag, Muhammad Robed Amin, Muhammad Shafiqul Bari, John Norrie, M. A. Faiz & Michael Eddleston
Toxicology Communications
Pesticide self-poisoning is one of the three most important global means of suicide, killing an estimated 110–168,000 people each year, mostly in poor rural Asian communities. Organophosphorus (OP) and carbamate anticholinesterase insecticides are responsible for about two-thirds of these deaths. Calcium channel blocking medicines (CCB) may reduce the effect of pesticides and prevent deaths.